Endocrine Abstracts

Assessment of basal calcitonin as the main marker of medullary thyroid cancer (MTC) was introduced into routine practice in the Republic of Belarus more than 10 years ago. A number of laboratory and clinical factors can influence the result of this parameter determination. Equally important is the gender, age, weight, the deviation of the serum calcium level, certain medications.The aim: Of the study was to develop and implement of stimulated calcitonin ...

Anacardium occidentale (cashew tree) belongs to the Anacardiaceae family and has been well used in folklore medicine for the treatment of various ailments such as gastrointestinal disorders, hypertension and diabetes. Literature is replete with reported anti-diabetic actions of cashew leaf. The molecular mechanism of the hypoglycemic activity of A. occidentale was investigated in this study. Insulin, Glucagon like peptide-1 (GLP-1), dipeptidyl peptidase-4 (DP...

Adrenocortical cancer is a rare, aggressive disease, requiring a fast and multidisciplinary approach. The genetics is heterogeneous so is also the clinical course. In the last 10 years, we have diagnosed and treated a number of 20 cases, aged at diagnosis between (34–74 years) (mean 55.9±12.87), followed up between (2–77 months) (mean 25.75±23.58). The maximal diameter of the tumor was (5.5–25) (mean 10.95±5.43). The secretion profile was Cushing ...

Introduction: Fragility fractures are increasingly recognized as a complication of diabetes mellitus (DM). Disease duration, poor glycemiccontrol, diabetes complication, and glycemic variability may be associated with increased risk.Aim: To investigate the association between glycemic control and hip fracture (HF) risk in a cohort of diabetic patients.Methods: This retrospective cohort study included all patients 50 years and older...

Background: First-line therapy of ACTH-independent Cushing’s Syndrome (CS) is the resection of the underlying tumor in all cases. After surgical cure of CS, most patients develop transient secondary adrenal insufficiency with a variable time of recovery. Adrenal function testing can identify patients who may require glucocorticoid replacement.Methods: We reviewed 61 patients diagnosed with ACTH-independent CS excluding 6 with adrenocortical carcinom...

The incidence of Graves disease in different regions of Russia ranges from 20 to 50 cases per 100000 population.Purpose: To improve the results of surgical treatment of patients with Graves disease by identifying the optimum amount of remaining thyroid tissue and prediction of thyroidal status in the long term.Methods and design: The 138 patients with Graves disease operated over the past 10 years: 131 women (94.9%) and 7 men (5.1%...

Aim: Chromolaena odorata and Tithonia diversifolia have been combined as folkloric treatment for pediatric anemia. However, the underlying molecular mechanism of this pharmacology has not been established. This study sought to establish the effects of these plants on erythropoietin (kidney), and erythropoietin receptor (bone marrow) expression and to monitor cyclin-dependent kinase inhibitors, and FasL/FAS signaling mechanism therefrom....

Background: Struma ovarii, defined as containing 50% or more thyroid tissue is rare and accounts for 1% of ovarian tumours. Presentation is non-specific, relating to mass effect. Although the tumour predominantly consists of thyroidal tissue, features of hyperthyroidism occur in <5% of cases. Majority are benign, histological features of thyroid cancer are found in about 5–10%. Seventy per cent of these are papillary thyroid cancer (PTC). We present a case of struma o...

Introduction: Thyrotoxicosis is a common endocrine disorder; variable degree of hepatic dysfunction is often seen with thyrotoxicosis. Severe liver dysfunction associated with thyrotoxicosis occurs rarely. The prevalence of liver abnormality with thyrotoxicosis is reported to be ~ 15–30%. The mechanism of liver abnormality is not well understood; direct thyroid hormone mediated hepatocyte injury has been raised as a possible mechanism. We conducted a retrospective review ...

Introduction: T2DM prevalence in Belarus is 3.489.5 per 100 thousand people, annual growth rate is 5–6%. STEPS study: in 2016–2017 the following risk factors prevailed: overweight and obesity (61.2%), dyslipidemia (36%), hypertension (50%); inactive lifestyle (78.2%). The study aim was to assess risk factors for metabolic disorders in a young healthy population. Objective. 253 people were examined: 22.1% of men and 77.9% of women under 40. Methods: We performed ant...